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AbbVie Senior Scientist II in Worcester, Massachusetts

The Biotherapeutics group within AbbVie Discovery is seeking a highly motivated Senior Scientist with a strong understanding of therapeutic discovery and machine learning to join the Cell and Functional Biology team at the AbbVie Bioresearch Center (ABC). The ABC site, based in Worcester, MA, offers the unique setting where Biologics drug discovery, development and manufacturing coexist in one location. Our team interacts with multidisciplinary groups across AbbVie and is focused on developing solutions for Immunology, Neurology, Virology, Oncology, Eye and Aesthetic diseases and conditions. We employ innovative approaches, advanced multiplex screening assays and automation platforms to empower biotherapeutic discovery against complex targets.

As an integral part of the group, the ideal candidate will:

•Conceptualize and implement machine learning and AI algorithms to predict and optimize protein properties, focused on designing safe therapeutic solutions.

•Contribute experimentally to molecular and cellular biology including assay design and optimization.

•Take an active role in ML/AI roadmap development for novel antibody designs, driving information system infrastructure readiness for binding and functional assay data, and establishment of best practices in advanced knowledge base analytics.

•Develop close cross-functional relationships with data and small molecule discovery scientists for partnered solutions to common challenges.

•Demonstrate scientific excellence through dedication to multiple projects in a fast-paced multi-disciplinary environment


•BS, MS or PhD with 10-12 (BS), 8-10 (MS), 0-4 (PhD) years of industry or academic experience

•Experience with wet lab immunological assays (ELISA, Flow cytometry, Functional/Reporter)

•Experience with generative modeling of biological systems/data

•Strong attention to quality and details when exercising organizational, documentation and interpersonal skills

•Proven flexibility to deal with changing timelines and shifting work priorities


•Experience with advanced automation platforms and programming

•Experience with high-throughput biotherapeutic screening applications

•Experience with external collaborations and partnerships

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.