Job Information
Alloy Therapeutics Scientist, Protein Engineer in Waltham, Massachusetts
The Company
We are Alloy Therapeutics —a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.
Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.
This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team!
The Team
The Alloy Protein Sciences team supports the Alloy Discovery Services (ADS) team with custom recombinant protein production with focus on antibody-based drug formats and engineered cell lines. As a core group of ADS, the team is integral to every discovery campaign. Protein Science leverages established protocols to deliver on project timelines, while also innovating new techniques to drive efficiency and advance the field. The team has a strong focus on the integration of automation to support high-throughput processes.
The Role
You will work within our Protein Sciences team to innovate, improve, and strengthen our internal industrial biological production technologies at Alloy. You will be using and helping to develop the latest in protein production and purification techniques with the goal of making better medicines together with our collaborators. This role will report to our Head of Protein Sciences with autonomy owning various projects and tasks in a dynamic start-up environment while keeping up the pace of Alloy. This is you!
How You’ll Drive Impact
Produce: Maintain and expand a steady production capacity, delivering high quality material consistently
Design: Engineer bi and tri specific antibody formats for optimal biological function and production efficiency.
Innovate: Ideate and test new methods for recombinant protein production & purification.
Coordinate: Your activities with upstream and downstream teams to streamline activities across ADS
Automate: Implement advanced automation techniques across our FPLCs to streamline our protocols with the goal of expanding the number of fully automated two step productions
Principal Responsibilities
Recombinant production and purification of bispecific and trispecific antibody formats
Recombinant production of bespoke non-antibody molecules for use as immunogens and project
support reagents
Protocol development and optimization with a focus on automation of mid-scale purification from
end to end
Lead the design of multi-specific and other custom protein formats
Collaborate and serve as a SME for recombinant production on project teams
Lead projects internally on client’s behalf
Qualifications
You have a PhD, Masters, or BS/BA in an appropriate scientific discipline (cellular or molecular biology, biochemistry, chemistry, etc.) with 0-1, 3+, or 8+ years, respectively, of research experience working with recombinant DNA and/or proteins in support of the discovery of biologics
You have a track record of improving production processes and a history of producing difficult to purify molecules
You have experience with protein expression across a wide range of hosts (bacteria, insect, mammalian) and multiple chromatography methodologies and tags (affinity, SEC, HIC, IEX)
You have experience with analytical assays for recombinant proteins (a-SEC, Light Scattering, Mass Spec, SDS-PAGE, etc.)
You have a track record of engineering solutions and a structure-based design approach
You are a self-starter and think outside the box. You are unafraid to challenge convention. You are driven.
It is a plus if you have experience with project management in a customer focused environment
You pay attention to details, and you practice rigorous scientific thinking & clear communication skills
You have sense of urgency, speed, persistence, and organization and prefer a dynamic, fun, and exciting work environment
Ability to work across various US and international time zones
Accommodate occasional travel as needed (<5%)
Taking Care of Our People
We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation
Competitive base and equity compensation commensurate with level of experience and independence
401(k) company match
Health & Family
Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
Company-paid disability (STD, LTD) and life insurance
Paid parental leave
Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
Unique Perks
Unlimited PTO (paid time off) and flexible schedules
Annual stipend for continuing education with commitment to your career through individualized professional development plan
Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness
Diversity, Equity, and Inclusion
Here at Alloy, we democratize capabilities for discovering and developing therapeutic biologics. So, being diverse and inclusive isn’t just something we strive for, it is who we are, and part of what we do each and every single day. We want to ensure that as an employee, you feel Alloy is a place where, no matter who you are, you feel safe, included, and that you have the opportunity to bring your unique self to work.
Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at recruiting@alloytx.com . We will make every effort to respond to your request for disability assistance as soon as possible.
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