Job Information
Alloy Therapeutics Research Associate – Oligonucleotide Discovery in Waltham, Massachusetts
The Company
We are Alloy Therapeutics —a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN.
Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.
This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team!
The Team
The Alloy RNA Medicines group is innovating a novel RNA-based drug discovery platform, namely “AntiClastic”, spanning the fields of antisense therapeutics to immunomodulating therapeutics. The team works closely with external partners to discover and develop AntiClastic RNA medicines.
The Role
As a Research Associate, you will work within the RNA Medicine team in Waltham, MA. You will also collaborate with internal/external partners on nucleic acid drug discovery projects to ensure timely execution of the experiments, and delivery of high-quality data. This role will have an autonomy owning various stakeholders, projects, and tasks in a dynamic start-up environment while keeping up the pace of Alloy. This is you!
This role will report to our RNA Senior Scientist with autonomy owning various stakeholders, projects, and tasks in a dynamic start-up environment while keeping up the pace of Alloy. This is you!
How You’ll Drive Impact
Innovate: Develop novel assays to elucidate the mechanism of action of novel ASO formats.
Deliver: Design, execute, analyze, and interpret in vitro and in vivo experiments. Generate robust, high-quality data.
Collaborate: Work closely with internal/external partners on drug discovery projects to ensure studies are executed to meet scientific goals and timelines.
Principal Responsibilities
Design and execute several molecular biology and protein techniques including, but not limited to, nucleic acid isolation, RT-qPCR, western blots and ELISA.
Culture various cell types including established cell lines, primary cells and iPSCs.
Perform a range of cell-based assays, including those utilizing microscopy and plate readers for fluorescence/luminescence detection.
Process mouse tissue for nucleotide extraction and downstream analysis.
Operate high-throughput tools, including 96 channel electronic pipets to streamline and enhance experimental workflows.
Analyze data using GraphPad software and prepare presentation-ready images to effectively communicate experimental findings.
Maintain comprehensive and accurate records of all experiments using the Benchling electronic notebook, ensuring meticulous documentation and data integrity
Qualifications
B.S. or M.S. degree in Biology or related science.
1 to 3 years of additional experience in biotech/pharma.
Knowledge of antisense oligonucleotide modalities and their mechanism of action.
Previous Experience working with ASOs is highly desirable.
Experience designing and running molecular biology, protein and cell-based assays.
Taking Care of Our People
We support the individuality of what people need to do outside of work to empower them to do their best at work. While you focus on making better medicine together, we focus on programs and benefits that support a diverse and growing team. Whether you’re single, in a growing family, or nearing retirement, Alloy offers a variety of comprehensive and competitive benefits starting from day one.
Compensation
Competitive base and equity compensation commensurate with level of experience and independence
401(k) company match
Health & Family
Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
Company-paid disability (STD, LTD) and life insurance
Paid parental leave
Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
Unique Perks
Unlimited PTO (paid time off) and flexible schedules
Annual stipend for continuing education with commitment to your career through individualized professional development plan
Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness
Diversity, Equity, and Inclusion
Here at Alloy, we democratize capabilities for discovering and developing therapeutic biologics. So, being diverse and inclusive isn’t just something we strive for, it is who we are, and part of what we do each and every single day. We want to ensure that as an employee, you feel Alloy is a place where, no matter who you are, you feel safe, included, and that you have the opportunity to bring your unique self to work.
Alloy Therapeutics is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, veteran status, disability, or other legally protected status. If you are unable to submit an application because of incompatible assistive technology or a disability, please contact us at recruiting@alloytx.com . We will make every effort to respond to your request for disability assistance as soon as possible.
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