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Novartis Pharmaceuticals SynBio/Gene Therapy Expert (Principal Scientist) in Cambridge, Massachusetts

353683BR Job ID: 353683BR Job Description: 25 Cell and Gene Therapies have been approved so far, but the FDA believes that we are just at the beginning and expects an approval rate of 10 - 20 Cell and Gene Therapies per year by 2025. As an expert within the Engineered Therapeutics Group of Chemical Biology & Therapeutics in NIBR-Cambridge, you will be part of a team developing the next generation of Cell and Gene Therapies. Within the last 2 years our group has made major progress in developing a modular technology platform, SmartTherapeutics, that allows the rapid testing of self-regulating Cell and Gene Therapies. In addition, we prototyped technologies that will allow us to deliver these circuits to cells using currently available vector technologies. Alongside our colleagues in the Ophthalmology department, we are now initiating in vivo experiments to show the feasibility of our approach. The Engineered Therapeutics Group is embedded in the Genome Science Home which consists of more than 60 scientists across Basel, San Diego, and Cambridge, with diverse expertise from genome engineering, next gen sequencing, and high throughput genetic screens. You will focus on 1) further expanding the SmartTherapeutics toolbox as well as pushing forward the deployment of this technology in collaboration with multiple disease areas and 2) developing new tools for epigenetic editing. Your responsibilities include, but are not limited to: - Develop and optimize novel sensors for our SmartTherapeutics platform. - Develop novel tools for epigenetic editing in collaboration with internal /external experts as needed to execute on proof-of-concept studies. - Conceive novel project concepts, build and lead a cross-functional team for carrying out the strategy, including significant leading from the bench. - Participate in due diligence teams to evaluate potential in-licensing or partnering opportunities - Communicate effectively with diverse project teams, and present to departmental and institutional leadership. \n\n\n\n Position Title: SynBio/Gene Therapy Expert (Principal Scientist) Minimum requirements: What you’ll bring to the role: - PhD training in synthetic biology and gene editing. Direct, hands-on experience with developing and testing synthetic biology applications in mammalian cells is highly desired. - Knowledge and experience (either direct or via collaboration) in developing zinc finger or TALE proteins for genome targeting is highly valued. - Demonstrated leadership and/or mentoring experience. - Comfort in a collaborative, collegial, non-hierarchical, highly-dynamic matrixed environment. - Excellent oral and written communication skills, including the ability to speak to audiences and collaborators at all levels, internally or externally. Desirable Skills: - Knowledge of and/or experience in epigenetic regulation. Why Novartis? 766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working. We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis! Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: Job Type: Full Time Country: USA Work Location: Cambridge, MA Functional Area: Research & Development Division: NIBR Business Unit: CBT - NIBR Employment Type: Regular Company/Legal Entity: NIBRI Commitment to Diversity & Inclusion:: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. Shift Work: No Early Talent: No