Pfizer Sr. Scientist, Computational Biology in Cambridge, Massachusetts
As part of the Computational Sciences, apply computational and statistical analysis to interpret large-scale transcriptomics, functional genomics, proteomics, and human biology data for the advancement of small molecule and biologic discovery projects. The successful candidate will be responsible for performing integrative analysis relating multi-omics measurements with in vitro/in vivo/clinical biological endpoints and complex phenotypes and deliver testable hypotheses.
Perform computational analysis of high-dimensional datasets from model systems, with a focus on mechanism of action studies, mechanisms of resistance, and effective therapeutic combinations through the translation of bioinformatics data.
Deliver testable hypotheses/insights from complex multidimensional data to inform target/compound selection in high quality presentations & publications.
Identify and validate innovative approaches to improve quality and efficiency of hypothesis generation from experimental data
*Maintain awareness of emerging methods in computational biology and applications for novel omics technologies
Provide ad-hoc bioinformatics support to cross-disciplinary project teams
Serve as Computational Biology liaison to Medicinal Sciences project teams
Participate in analysis work groups and contribute innovative bioinformatics analysis to consortium-based projects
PhD in Bioinformatics, Biostatistics, Biological Sciences, relevant natural sciences required,
2-3 years relevant experience applying quantitative approaches to solving biological problems, ideally in a pharmaceutical, biotech or comparable context.
• Strong background in human biology/medicine.
• Demonstrated experience in design and interpretation of in vivo and/or in vitro biological experiments.
• Demonstrated expertise in delivering insights/hypotheses from complex multi-dimensional biological data in a biomedical context.
*Demonstrated experience in handling NGS and other omics datasets
• Demonstrated experience applying computational and statistical approaches to deliver insights/hypotheses, e.g. multivariate and machine learning approaches.
• Demonstrated ability to effectively interface with biologists to communicate and discuss results, ideas, and follow-up experiments.
• Exceptional communication skills (oral and written) as demonstrated by publications & presentations.
- Deep understanding of the statistical methods commonly used in omics analysis
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
Other Job Details:
Eligible for Employee Referral Bonus:
Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.