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Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

The Mechanisms of Cancer Resistance Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology, and leading academic research centers in the area .

We are seeking a highly motivated Sr. Associate Scientist with a strong biology and cell-based assay background to join the MOCR Oncology Discovery Biology group (ODB II) team. This individual will design, validate, execute, and interpret novel cell-based assays supporting biology target validation. This individual will be able to work on cross-functional drug discovery teams, closely interacting with colleagues from different functions, including chemistry, LDO, DMPK, and pharmacology. In addition, the candidate will collaborate within LDO and across project teams to help shape the in vitro screening strategy, identify appropriate assay detection formats, and develop high throughput assays using cutting-edge automation platforms. The ideal candidate will have solid hands-on experience in HTRF, BRET, luminescence, Fluorescence, ALPHA technology, MSD, and qPCR assay formats. Prior experience in running high-content imaging and FACS-based assays is a plus. This is a laboratory-based position.

Duties/Responsibilities:

• Collaborate with colleagues across R&D to develop high-quality cell-based assays.

• Adapt these assays for high throughput formats.

• Execute routine cell-based screening assays to ensure rapid data delivery.

• Analyze, interpret, and effectively report data at team meetings.

• Troubleshoot assays to ensure high-quality control.

• Interface closely with disease biology colleagues to ensure assays and screening efforts are aligned to the scientific project goals.

• Lead efforts to identify, evaluate, and implement new technologies and methods that push the boundaries of complex cell-based screening.

• Interface with Informatics and automation colleagues proactively to drive the evolution of screening platforms and ensure adequate maintenance of the cell-based assay infrastructure.

Key Experiences and Qualities :

• Demonstrated hands-on experience in developing various functional cell-based signaling assays in primary cells and engineered cells.

• Experience with automated liquid handlers, plate readers, software and robotics is highly desirable.

• Expertise in databases, data analysis & analytics, and specialized analysis tools is preferred.

• Strong analytical skills and the ability to troubleshoot experimental problems independently is required.

• High content image screening and flow cytometry platforms experience is a plus.

• Self-motivated and a proven ability to work in a multifunctional team setting.

• Detail-oriented, highly organized with the ability to run multiple projects.

• Excellent interpersonal and communication skills

• Ability and desire to master new skills, methods, and technologies that enhance departmental capabilities.

Basic Qualifications

• Bachelor's Degree and 4+ years of academic / industry experience

• Master's Degree and 2+ years of academic /industry experience

Preferred Qualifications:

• MS degree in molecular biology, cell biology, pharmacology, or a related field

• MS with 2+ years of relevant research experience in assay development & execution, preferably in drug discovery in industry settings

• Highly self-motivated & fueled by a fundamental interest in contributing to science in general and drug discovery in particular.

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company: Bristol-Myers Squibb

Req Number: R1582324

Updated: 2024-06-21 03:31:01.984 UTC

Location: Cambridge Crossing-MA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.