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Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

The Oncology Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

The new Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Responsibilities:

In the role as a Sr. Scientist within Discovery Pharmacology and In vivo Biology, the ideal candidate will:

• Apply scientific, technical skills and functional knowledge to conduct in vivo pharmacology experiments and studies for T cell engager drug discovery programs. Working closely with project teams and key stakeholders, design, execute and deliver in vivo studies from target concept to Proof of Concept in patients.

• Characterize therapeutic candidates in vivo as part of the lead selection process, including tumor target antigen expression, T cell immunophenotyping, T cell dependent cytotoxicity and cytokine release assays building PK PD and efficacy relationship.

• Develop state of the art in vivo models, experimental protocols and relevant IO assays. Strengthen department's overall T-cell engager capabilities and expertise by employing innovative methods and technologies to test therapeutic hypotheses.

• Working with cross-functional teams participate in implementation of program strategy, including xenograft models, PKPD and efficacy studies, and translational strategies to support regulatory filings.

• Execute experiments and deliver comprehensive high quality data sets to help decision making in a timely manner. Analyze results of complex experiments and present comprehensive technical or project reports at project team meetings.

• Mentor and train junior level research associates.

Basic Qualifications:

• Bachelor's Degree

• 7+ years of academic and / or industry experience

Or

• Master's Degree

• 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

• 2+ of academic and / or industry experience

Preferred Qualifications:

• Bachelor's Degree with 7+ years or Master's Degree with 5+ years of relevant of academic and / or industry experience industry experience in in vivo pharmacology and expertise in preclinical development of T and/or NK cell engagers and immune-oncology.

• Experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models, IVIS imaging to enable candidate selection for early clinical development is required.

• Skilled and proficient at independently conducting xenograft mouse studies to perform model development, anti-tumor efficacy, PK/PD and combination studies in conjunction with necropsy/tissue/blood collection across multiple projects with delivery of high-quality data.

• Proficiency in cell culture, passaging and harvesting cells is required. Skilled at murine dosing via PO, IP, IV, SC routes.

• Attention to detail with excellent organizational and record keeping skills is a requirement. Ability to work collaboratively across departments, understand and implement applicable regulations around animal care/safety/handling desired.

• Extensive expertise with multi-parameter flow cytometry to investigate immune function of tumor infiltrating lymphocytes is highly desired.

• Demonstrated expertise in utilizing relevant pharmacodynamic ex-vivo assays such as MSD ELISAs, qPCR, Luminex, western blotting.

• Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation is required.

• Excellent interpersonal and communication skills with the ability to interact effectively with internal colleagues is required.

#LI-Onsite

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company: Bristol-Myers Squibb

Req Number: R1590035

Updated: 2025-03-14 01:10:03.389 UTC

Location: Cambridge Crossing-MA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.