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Sanofi Group Senior Principal Scientist, Lab Head in Cambridge, Massachusetts

Position Overview:

Immune Profiling Lab Head, Precision Immunology Cluster

The Immunology and Inflammation Research and Early Development Therapeutic Area in Sanofi is building a world-class immunology team and is seeking highly motivated scientists to lead a group of researchers evaluating novel therapies in the fields of Type 2 Immunity and Fibrosis, Immune Checkpoint Biology, Type 1 Diabetes, Targeted Autoimmunity and Innate Immunity.

We are seeking an Immune Profiling Lab Head to lead a team in the Precision Immunology Cluster, part of our Immunology & Inflammation Research Therapeutic Area.

The candidate will lead our cutting-edge precision immunology lab and will lead design and execution of experiments for the molecular dissection of immune-mediated diseases and the identification of novel therapeutic targets and biomarkers for patient stratification. He/She will contribute deep scientific know-how and expertise in immunology and will develop strategies, formulate and explore hypotheses and interpret results from integrated experimental approaches, using cell- and immune-based assays and state-of-the-art high-throughput genomic and immune profiling technologies.

The candidate will work closely with other disciplines across Sanofi to drive cross-functional projects for identification of novel therapeutic targets and biomarkers. He/she will also coordinate the transition of early discovery research programs into early clinical development, providing scientific and technical leadership.

Key Responsibilities:

  • Lead a translational research group supporting immunology and inflammation research programs to understand the molecular aetiology of immune-conditions, identify relevant target genes and pathways, and develop biomarkers for patient stratification

  • Lead drug discovery project teams and champion projects from discovery into early clinical development.

  • Develop strategies and technologies to conduct experiments and analytical procedures, applying a wide variety of scientific principles and concepts.

  • Conceive, design and direct execution of cell- and immune-based assays, as well as immune profiling experiments using high-dimensional flow cytometry and single-cell genomics technologies.

  • Share and contribute scientific and technical know-how and experience with cluster team members.

  • Coordinate research efforts and make key scientific and technical contributions for the strategic development of cross-functional projects.

  • Synergize with computational biologists to devise high-throughput genomic and immune profiling strategies, interpret and validate results.

  • Build efficient interactions with collaborators within and outside the Immunology and Inflammation Research and Early Development Therapeutic Area.

  • Provide scientific expertise, establish and manage external scientific collaborations, monitor external market, and provide critical assessment.

  • Manage direct reports, including scientists and research associates. Provide scientific leadership to scientists and research associates and train the team and promote their career development.

  • Provide and promote support for operational excellence according to Sanofi values and ethics.

  • Prepare publications, research and clinical/regulatory documentation in accordance with Sanofi quality standards.

Basic Qualifications:

  • PhD in Immunology or related program with minimum of 8 years of industry or academic experience in immunology and in vivo pharmacology; or MS in Immunology or related program with minimum of 12 years of industry or academic experience in immunology and in vivo pharmacology.

  • Track record of recent scientific publications and high level of proficiency with high throughput profiling genomics and immune profiling technologies such as multi-color flow cytometry and mechanistic studies of immune regulation.

  • Previous experience in managing scientist(s).

Preferred Qualifications:

  • Experience with cross-functional projects involving the use of genomics and immune profiling data to generate novel hypotheses, and experimental analyses and validation using in-vitro and in-vivo models.

  • Experience with high-data content projects, in interaction with computational biologists and data analysts.

  • User-level proficiency in the use of flow-cytometry analysis software.

  • Experience with in vitro functional assays using human immune cells is highly desirable.

  • Strong people organizational and presentation skills.

  • Excellent written and oral communication skills.

  • Excellent interpersonal and team skills; track record of success working collaboratively across disciplines in a matrix environment.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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