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Sanofi Group Scientist Process Chemistry in Cambridge, Massachusetts

About the Job

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Position Overview:

The Process Chemistry team, part of the CMC Synthetics organization within Sanofi R&D, is responsible for the design and preliminary process development of commercial manufacturing routes for drug substances undergoing clinical development. Within Process Chemistry, the High-Throughput Innovation Technologies (HIT) team seeks to develop and deploy high-throughput experimentation, data-rich experimentation and automation processes into the Sanofi development toolbox. We strongly believe that innovation is an important driver to be successful and we focus a large part of our activity on developing new synthetic routes, concepts, and technologies to provide drug substances in the most efficient, robust, economical, environmentally benign, and intrinsically safe way.

We are looking for a highly motivated and collaborative individual with expertise in synthetic organic chemistry to join our Process Chemistry team. Under the direction of Process Chemistry leadership, the primary responsibilities of this role are to apply high-throughput and automation platforms and to perform and oversee multi-step route evaluation and route development activities, with the aim of establishing commercial drug substance manufacturing processes through management and execution of internal and outsourced laboratory activities. Depending on projects, this role may also oversee the activities of one or more collaborators.

Key Responsibilities:

  • Use high-throughput experimentation as a tool to elucidate chemical reactivity and drive route evaluation.

  • Develop and maintain automation workflows to accelerate reaction discovery and optimization.

  • Design novel synthetic pathway for drug substances in clinical development.

  • Conduct route scouting in laboratory to demonstrate synthetic viability.

  • Use all imaginable chemistry tools and methods to develop new synthetic pathways (photochemistry, biochemistry, flow chemistry, electrochemistry, on-line analysis, High Throughput Screening, structural analysis (NMR, UPLC/MS).

  • Analyze experimental data to drive synthetic experimental plans.

  • Assist in the design, planning and execution of multi-step experimental studies guided by risk assessment to deliver safe, efficient, robust and scalable drug substance manufacturing processes.

  • Investigate optimization and scale-up of reaction and purification unit operations.

  • Collaborate within project teams by working closely with analytical chemists, process engineers, pilot plant experts and project managers within the CMC Synthetics organization.

  • Communicate scientific results in a clear, concise, and accurate manner via electronic laboratory notebook documentation, development reports, project discussions and presentations.

  • Draft and review technical reports, external publications and patent applications.

  • May include management of outsourced laboratory activities: generating scope of work, supervising activities at CDMOs, validating reports for outsourced activities.

Basic Qualifications:

  • Ph.D. in organic or synthetic chemistry.

  • Experience with high-throughput experimentation.

  • Experience in chemocatalysis or biocatalysis including characterization of catalytic processes and/or mechanistic analysis.

  • Computational capabilities and basic coding skills.

  • Strong publication record in peer-reviewed journals.

  • Excellent written and verbal communication skills.

  • Ability to operate with flexibility in a dynamic environment and with tight deadlines.

Preferred Qualifications:

  • Post-doctoral experience.

  • Proficiency with Microsoft suite.

  • Knowledge in flow chemistry and/or advanced analytics

  • Familiarity with digital tools (e.g. Scifinder-n, and Reaxys) and advanced data analysis software (e.g. Spotfire).

  • Familiarity with automated laboratory equipment (e.g. Chemspeed, Mettler)

  • Design of experiment, statistical and/or thermo-kinetic modeling.

  • Strategic and innovative thinker with a track record of fresh insightful thinking by developing creative approaches to processes and practices.

  • French language skills.

Why Choose Us?

  • Bring the miracles of science to life alongside a supportive, future-focused team.

  • Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

  • Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

  • Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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