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Foghorn Therapeutics Research Associate/Senior Research Associate, Biochemistry & Biophysics in Cambridge, Massachusetts

About Foghorn

Foghorn Therapeutics is pioneering the discovery and development of a new class of medicines targeting genetically determined dependencies within the chromatin regulatory system, an untapped opportunity for therapeutic intervention. Our proprietary Gene Traffic ControlĀ® platform gives us an integrated, mechanistic understanding of how the various components of the chromatin regulatory system interact, allowing us to identify, validate and potentially drug targets within the system.?The Company, currently in pre-clinical stage, is advancing over 10 small molecule and protein degrader programs across a wide range of cancers.

Foghorn was founded in 2016 by Cigall Kadoch, Ph.D., Gerald Crabtree, M.D., and Doug Cole, M.D., of Flagship Pioneering. Learn more about Foghorn at?www.foghorntx.com.

About the Chromatin Regulatory System

The chromatin regulatory system regulates gene expression by directing the movement of molecules that turn genes on and off. Disease dependencies associated with the chromatin regulatory system are estimated to impact over 2.5 million cancer patients across the United States, Europe and Japan. This system is further implicated in neurological, autoimmune, and other serious diseases.

Job Summary

We seek a highly motivated, enthusiastic and collaborative researcher to join our Drug Discovery team in a lab-based role to support early discovery projects in oncology.

Key Responsibilities

  • Assess the function of enzymes and protein complexes through mechanistic and binding experiments

  • Design, develop and troubleshoot a variety of diverse biochemical and biophysical assays for use in the assessment of both mechanism and small molecule modulation of protein targets, including hit identification, validation and optimization

  • Analyze, interpret, and document data using an Electronic Laboratory Notebook and data analysis software tools

  • Contribute to group knowledge and expertise through collaboration and idea exchange, including presentations to multidisciplinary project teams

Qualifications

  • BA/BS or MS degree in Biochemistry, Biophysics, Enzymology or a related field with 0-3 years of relevant industry experience

  • A solid understanding of protein function and enzyme mechanism; experience with biochemical and biophysical assay development for protein target and small molecule inhibitor characterizations as well as protein-ligand binding interactions

  • Experience with fluorescence-based assay techniques (e.g., HTRF, FP, quench assays) and label-free technologies (e.g., ITC, DSF, SPR, MST) is desired

  • A basic understanding of compound management and ability to manage automated liquid handling instrumentation is desired

  • Demonstrated ability to analyze, interpret and present data in a clear manner

  • An interest in contributing to medicinal chemistry drug discovery efforts to evaluate compound SAR and mode of action characterization

  • The ability to learn new techniques quickly and a focus on attention to detail

  • Excellent communication and inter-personal skills

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