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KSQ Therapeutics Associate Scientist/Senior Associate Scientist/Scientist, Immunology in Cambridge, Massachusetts

At KSQ Therapeutics, we seek to understand the role of every human gene in each disease, each tissue, and each cell that we study. This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development. Utilizing this approach, we also identified a number of opportunities for the development of new medicines. As a result, we have aggressively invested in these distinct, highly validated pathways for new drug development with the expectation that the medicines we create may become the next breakthrough products for patients.

Founded in late 2015, KSQ is a preclinical-stage biotech that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo. The company has expanded the scope of its technology to include multiple cell types and to unlock areas beyond oncology. KSQ is led by a team of accomplished industry experts in drug discovery and development.

Position summary:

KSQ Therapeutics, Inc. is seeking a self-motivated and dependable Associate Scientist/Senior Associate Scientist/Scientist to join our Immunobiology team. Our ideal candidate thrives in a research environment that demands scientific rigor and technical excellence. Applicants with an interest in autoimmune disease, innate cell and T cell immunology that have experience in mammalian cell culture, CRISPR-Cas9 technology and immune cell phenotyping are strongly encouraged to apply.


  • B.S. (Associate Scientist), M.S. (Senior Associate Scientist) or Ph.D. (Scientist) in immunology or related field

  • 1+ year(s) of experience in a relevant academic or biopharmaceutical setting

  • Proficiency in mammalian cell culture and aseptic cell culture techniques

  • Hands-on experience in diverse cell biology techniques (cell isolation, proliferation assays, etc.)

  • Experience in designing, performing, and interpreting the results of high-parameter flow cytometry

  • Experience in DNA and RNA isolation, PCR and, preferably, RNA-sequencing

  • Experience in CRISPR/Cas9 gene-editing tools and cloning techniques is a plus

  • Demonstrated commitment to quality and great attention to details

  • Excellent verbal/written communication and presentation skills

  • Ability to contribute to multiple parallel projects under demanding timelines

  • A record of significant achievement in research and scientific creativity in the areas of inflammation, autoimmunity, immuno-oncology and/or drug discovery

Key Responsibilities

  • Plan and conduct genome-wide CRISPR/Cas9 screens in vitro and in vivo

  • Design and execute cell-based functional assays for the validation of small molecule/cell therapy prototypes

  • Contribute to the development of strategies for the genetic engineering of antigen-specific T cells

  • Develop and deliver scientific presentations and reports in a fast and efficient manner

  • Participate in various aspects of small company capability building