Massachusetts Jobs

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

The Cellular Pharmacology group at the department of Quantitative Biosciences is seeking an innovative and experienced Senior Scientist with a strong background in cell signaling and in vitro models of immunology, inflammation, and oncology to join our Quantitative Biosciences Department at our Company Research Laboratories in Boston. The successful candidate will play an essential role in developing assays in cellular context for screening and translational relevance. The alignment of these screening and translational assays with biochemical, ex-vivo and in-vivo approaches will greatly enhance our capabilities in the discovery of innovative therapeutics.

Responsibilities:

• Working collaboratively with members of department and multi-functional drug discovery project teams to drive design and optimization of therapeutic candidates. The successful candidate will support cellular aspects of hit to lead optimization efforts against a variety of targets across diverse therapeutic areas with different modalities.

• This individual will be expected to design and execute multiple cell based assays with deep comprehension of cell signaling to implement assay automation, new technologies, rigorous data analysis techniques quality control and work with research database in order to identify lead molecules, evaluate the structure-activity relationships and to characterize the mechanisms of action comprehending the biochemical and biophysical approaches.

• Identify and apply emerging innovative methodologies to the development of advanced fit for purpose in vitro models in support of research projects targeting inflammation, autoimmune indications, and oncology.

• Establish novel translational in vitro approaches that represent human disease pathology to answer cellular signaling, target engagement, translation and mechanistic questions.

• Function and communicate effectively in a highly productive and multi-disciplinary environment.

Education Requirements:

• B.S./B.A. degree with a minimum 8+ years of industry experience; or an M.S. degree with 6+ years of industry experience; or a PhD in immunology, oncology, pharmacology or related field with a minimum of 0-3+ years post-Ph.D. experience [academia/industry] with good publications.

Required Experience:

• Proficiency in primary immune cell isolation and stimulation, flow cytometry, proliferation and apoptosis assays, and immunoassay techniques/platforms (e.g. Western, ELISA, Mesoscale) to measure signaling intermediates and cytokines.

• Hands-on knowledge in developing robust in vitro models with engineered and primary cell lines, 3D and co-culture systems for investigations on target biology and screening in immunology/cancer biology.

• Good understanding of routine molecular biology, QRT-PCR , protein chemistry, cell line generation and imaging techniques.

• Candidate should be a strong team player with excellent oral and written communication skills and with a demonstrated ability to solve problems independently and excel in a cross-functional team.

• Demonstrated ability to thrive in a fast-paced environment.

Preferred Experience:

• Experience adaptive and/or innate immune cell biology with strong hands-on experience in human T cells is preferred.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

OEB4, OEB5

Job Posting End Date:

07/11/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date: 07/11/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R300979