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A full-time position is available for a highly motivated research technician at the translational immunogenomics laboratory (TIGL). The technician will contribute to new technologies for characterizing T cell specificity and neoantigen peptide properties in cancer and infectious disease. The laboratory uses various techniques in immunology, cell culture, molecular biology, protein engineering, and mass-spectrometry to develop and scale high throughput methods for mapping the antigen specificity of millions of T cells using single-cell RNA sequencing. TIGL also takes part in DFCI Neoantigen based cancer vaccine trials, and all the patient samples are analyzed in TIGL laboratories. The technician will be responsible for immune monitoring of ongoing Neoantigen-based cancer vaccine trials, protein purification, preparing samples for mass-spectrometry, and cellular immunology workflows, including flow cytometry and single-cell RNA seq. The technician should have excellent record-keeping skills and a drive to work develop new methods in single-cell immunology. Training is available in all protocols and procedures; experience with basic techniques in cell culture and biology is strongly preferred. Previous experience with computational biology and single cell analysis is beneficial.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

The candidate will be expected to independently carry out essential research functions in the laboratory that include but are not limited to experience in cell and molecular biology techniques.

Specifically, the candidate is expected to:

• conduct standardized immunological, biological, microbiological or biochemical tests and laboratory analyses, including the collection of information and samples from organic substances, such as blood, tumor biopsies, drugs, and animals;

• set up, adjust, calibrate, clean, maintain and troubleshoot equipment;

• clean, maintain and prepare supplies and work areas and may be responsible for ordering of supplies;

• collaborate with DFCI Purchasing;

• isolate, identify and prepare specimens for examination;

• analyze experimental data and interpret results to write reports and summaries of findings, including grant preparation and presentations, and look for opportunities to co-author publications;

• participate in formal and information presentations of results to staff;

• participate in grant application process and manuscript preparation as required;

• maintain detailed notebooks of all work-related activities;

• monitor laboratory work to ensure compliance with Environmental Health and Safety information, as well as the standard operating procedures specific to each laboratory.

• provide intellectual and interactive commitment to the position by keeping up with appropriate literature and research publications;

• be responsible for the development, modification and improvement of standard operating procedures;

• use computers, computer-interfacing equipment, robotics or high-technology applications to perform work duties;

• be responsible for designing and executing advanced experiments and setting strategy; and

• be responsible for the examination of animals and specimens to detect the presence of disease or other problems.

SUPERVISORY RESPONSIBILITIES:

Research Technician

No supervisory responsibilities. Normally receives detailed instructions on all work.

The ideal candidate should possess strong communication and organizational skills, attention to detail, and the ability to perform in a team environment. In addition, the position requires:

• a bachelor's degree required, with a major in biology or chemistry preferred;

• previous laboratory experience, with work in cell culture;

• knowledge of information and techniques related to either biology, chemistry or medicine is preferred;

• excellent communication skills (written and verbal) and the ability to work with a wide variety of faculty and staff;

• the ability to analyze information and use logic to address work-related issues and problems;

• strong attention to detail and thorough completion of work tasks; and

• the ability to work within a team environment.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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